Masatsugu Horiuchi Selected Research

Atherosclerosis

6/2012	Deletion of the angiotensin II type 1a receptor prevents atherosclerotic plaque rupture in apolipoprotein E-/- mice.
2/2012	Roles of interleukin 17 in angiotensin II type 1 receptor-mediated insulin resistance.
1/2012	Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation.
9/2008	Essential role of angiotensin II type 1a receptors in the host vascular wall, but not the bone marrow, in the pathogenesis of angiotensin II-induced atherosclerosis.
2/2008	Diabetes-associated cognitive impairment is improved by a calcium channel blocker, nifedipine.
2/2008	Blockade of AT1 receptor improves adipocyte differentiation in atherosclerotic and diabetic models.
10/2007	Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis.
6/2006	Regression of atherosclerosis by amlodipine via anti-inflammatory and anti-oxidative stress actions.
4/2006	Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation.
9/2005	Deletion of angiotensin II type 2 receptor exaggerated atherosclerosis in apolipoprotein E-null mice.

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Masatsugu Horiuchi Research Topics

Disease

25	Cognitive Dysfunction 04/2020 - 07/2006
19	Vascular Remodeling 10/2016 - 10/2002
18	Stroke (Strokes) 10/2018 - 11/2006
16	Hypertension (High Blood Pressure) 01/2017 - 02/2006
16	Vascular System Injuries 01/2016 - 01/2002
16	Insulin Resistance 12/2015 - 09/2002
14	Inflammation (Inflammations) 09/2013 - 11/2004
13	Atherosclerosis 06/2012 - 11/2004
11	Brain Ischemia (Cerebral Ischemia) 11/2015 - 08/2004
8	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 10/2008
8	Neointima 10/2016 - 01/2002
8	Cardiomegaly (Heart Hypertrophy) 01/2016 - 01/2002
8	Body Weight (Weight, Body) 12/2015 - 12/2006
6	Dementia (Dementias) 04/2020 - 09/2009
6	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2016 - 12/2004
6	Glucose Intolerance 02/2011 - 09/2002
5	Type 2 Diabetes Mellitus (MODY) 12/2015 - 02/2008
5	Fibrosis (Cirrhosis) 07/2013 - 01/2002
4	Infarction (Infarctions) 01/2016 - 05/2003
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 08/2012 - 05/2007
3	Muscle Weakness 01/2021 - 01/2019
3	Brain Injuries (Brain Injury) 10/2018 - 09/2008
3	Ischemia 11/2015 - 12/2004
3	Diabetes Mellitus 05/2013 - 04/2009
3	Atherosclerotic Plaque (Atheroma) 06/2012 - 11/2004
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2012 - 01/2004
3	Hypertrophy 05/2010 - 03/2005
2	Neurologic Manifestations (Neurological Manifestations) 10/2018 - 11/2006
2	Fetal Growth Retardation (Intrauterine Growth Retardation) 03/2018 - 01/2016
2	Obesity 01/2016 - 01/2013
2	Essential Hypertension 01/2014 - 01/2011
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2013 - 04/2009
2	Multiple Sclerosis 01/2013 - 04/2009
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 03/2010 - 09/2009

Drug/Important Bio-Agent (IBA)

40	Angiotensin IIIBA 01/2021 - 05/2003
24	Type 2 Angiotensin ReceptorIBA 01/2019 - 05/2003
15	olmesartanIBA 10/2014 - 10/2002
15	Type 1 Angiotensin ReceptorIBA 03/2014 - 03/2005
13	AngiotensinsIBA 01/2018 - 01/2002
13	Polyethylene (Polythene)IBA 01/2016 - 08/2002
11	compound 21IBA 10/2018 - 01/2012
11	Glucose (Dextrose)FDA LinkGeneric 12/2015 - 09/2002
10	Valsartan (Vals)FDA Link 05/2011 - 01/2002
9	Superoxides (Superoxide)IBA 04/2020 - 02/2004
9	Messenger RNA (mRNA)IBA 01/2016 - 05/2003
9	Proteins (Proteins, Gene)FDA Link 01/2016 - 03/2005
9	Insulin (Novolin)FDA Link 09/2013 - 05/2004
9	ApolipoproteinsIBA 06/2012 - 11/2004
7	Telmisartan (Micardis)FDA Link 05/2012 - 01/2008
7	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 02/2011 - 02/2004
6	PPAR gammaIBA 10/2018 - 10/2008
5	Angiotensin-Converting Enzyme 2IBA 01/2020 - 11/2011
5	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2019 - 01/2012
5	Angiotensin Receptor AntagonistsIBA 09/2015 - 12/2006
5	Antihypertensive Agents (Antihypertensives)IBA 04/2014 - 02/2009
5	Nifedipine (Adalat)FDA LinkGeneric 01/2014 - 01/2006
5	Angiotensin II Type 1 Receptor BlockersIBA 05/2012 - 12/2006
4	angiotensin I (1-7)IBA 01/2020 - 07/2012
4	2-chloro-5-nitrobenzanilideIBA 10/2018 - 10/2008
4	CytokinesIBA 01/2017 - 06/2012
4	LipidsIBA 01/2016 - 11/2004
4	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2015 - 02/2004
4	Apolipoproteins E (ApoE)IBA 06/2012 - 09/2005
4	ReninIBA 05/2011 - 02/2009
4	Estrogens (Estrogen)FDA Link 03/2011 - 01/2002
4	CholesterolIBA 01/2008 - 01/2003
4	azelnidipineIBA 12/2006 - 02/2004
3	NADP (NADPH)IBA 04/2020 - 06/2012
3	Amyloid (Amyloid Fibrils)IBA 04/2020 - 02/2012
3	Monocyte Chemoattractant ProteinsIBA 04/2020 - 01/2006
3	NADPH Oxidases (NAD(P)H oxidase)IBA 04/2020 - 02/2004
3	EnzymesIBA 01/2018 - 10/2014
3	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2017 - 01/2013
3	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2017 - 09/2002
3	SaltsIBA 11/2016 - 12/2007
3	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2016 - 11/2012
3	azilsartanIBA 04/2015 - 05/2007
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2015 - 02/2004
3	AldosteroneIBA 09/2013 - 05/2003
3	CollagenIBA 07/2013 - 08/2009
3	DNA (Deoxyribonucleic Acid)IBA 01/2012 - 08/2002
3	AngiotensinogenIBA 05/2011 - 02/2009
3	candesartanIBA 12/2007 - 09/2006
2	Receptor for Advanced Glycation End ProductsIBA 04/2020 - 10/2007
2	Interferon Regulatory Factor-1 (Interferon Regulatory Factor 1)IBA 10/2018 - 10/2016
2	salicylhydroxamic acid (SHAM)IBA 01/2018 - 11/2015
2	Peptides (Polypeptides)IBA 01/2017 - 01/2016
2	Rosuvastatin Calcium (Crestor)FDA Link 01/2016 - 11/2012
2	NAD (NADH)IBA 01/2016 - 02/2004
2	Matrix Metalloproteinases (MMPs)IBA 07/2013 - 06/2012
2	Irbesartan FDA LinkGeneric 11/2012 - 03/2011
2	propagermanium (Ge 132)IBA 11/2012 - 06/2011
2	Oxidoreductases (Dehydrogenase)IBA 06/2012 - 11/2004
2	LigandsIBA 01/2012 - 10/2007
2	Biomarkers (Surrogate Marker)IBA 12/2011 - 04/2011
2	Neuroprotective AgentsIBA 03/2011 - 12/2004
2	Losartan (Cozaar)FDA LinkGeneric 08/2010 - 10/2008
2	p38 Mitogen-Activated Protein KinasesIBA 05/2010 - 10/2008

Therapy/Procedure

2	Oral Administration 01/2017 - 12/2007
2	Ligation 06/2012 - 05/2003